Metabolic Labeling and Imaging of Cellular RNA via Bioorthogonal Cyclopropene−Tetrazine Ligation
Zhiyong He, Shuang Peng, Qi Wei, Shaokang Jia, Shan Guo, Kun Chen, Xiang Zhou
Abstract
RNA labeling is vital for the study of an RNA structure, cellular distribution, localization, and metabolism. Herein, we report N6 cyclopropane-modified adenosine (cpA) as a new analog for metaboli...
Topics & Concepts
Bioorthogonal chemistryTetrazineCyclopropeneChemistryLigationRNAComputational biologyBiochemistryBiologyCombinatorial chemistryClick chemistryMolecular biologyOrganic chemistryGeneClick Chemistry and ApplicationsFluorine in Organic ChemistryRNA modifications and cancer