Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations
Shane Miersch, Zhijie Li, Reza Saberianfar, Mart Ustav, James Brett Case, Levi L. Blazer, Chao Chen, Wei Ye, Alevtina Pavlenco, Maryna Gorelik, Julia Garcia Perez, Suryasree Subramania, Serena Singh, Lynda Ploder, Safder S. Ganaie, Rita E. Chen, Daisy W. Leung, Pier Paolo Pandolfi, Giuseppe Novelli, Giulia Matusali, Francesca Colavita, Maria Rosaria Capobianchi, Suresh Kumar Jain, Jyoti Gupta, Gaya K. Amarasinghe, Michael Diamond, James M. Rini, Sachdev S. Sidhu
Topics & Concepts
AvidityBivalent (engine)PotencyVirologyAntibodyNeutralizing antibodyChemistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MutantCoronavirus disease 2019 (COVID-19)BiologyVirusIn vitroBiochemistryImmunologyMedicineInfectious disease (medical specialty)GenePathologyMetalDiseaseOrganic chemistrySARS-CoV-2 and COVID-19 ResearchMonoclonal and Polyclonal Antibodies ResearchViral Infections and Immunology Research