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Augmenting AMPA receptor signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery

Laureen D. Hachem, Homeira Moradi Chameh, Gustavo Balbinot, Andrea J. Mothe, Alain Pacis, R. Li, Taufik A. Valiante, Wei Lü, Charles H. Tator, Michael G. Fehlings

2025Nature Neuroscience7 citationsDOI

Topics & Concepts

AMPA receptorNeuroscienceSpinal cord injuryEpendymal CellSpinal cordGlutamate receptorBiologyCell biologyNeural stem cellConditional gene knockoutZebrafishReceptorCorticospinal tractCell migrationCentral nervous systemKnockout mouseNeurotransmitter receptorEndogenyCellNeurotransmitterSignal transductionAstrocyteCell typeCell signalingChemistryRegeneration (biology)Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsNerve injury and regeneration
Augmenting AMPA receptor signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery | Litcius