Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle
Ryan K. Perkins, Kaleen M. Lavin, Ulrika Raue, Bożena Jemioło, Scott Trappe, Todd A. Trappe
Abstract
Findings from this investigation provide novel insight into the effect of aging and lifelong aerobic exercise on structural components of the innate immune system in skeletal muscle of humans. Data presented here suggest aging increases basal expression of select Toll-like receptors (TLRs), and lifelong exercise does not impact this age-related increase. Additionally, acute exercise stimulates gene expression of several TLRs, while the adaptor response is likely dysregulated with aging and maintained with lifelong exercise.
Topics & Concepts
Innate immune systemSkeletal muscleInternal medicineAerobic exerciseEndocrinologyTRIFBasal (medicine)TLR4Vastus lateralis muscleTLR3Immune systemReceptorAgeingAnabolismMedicineToll-like receptorChemistryImmunologyInsulinExercise and Physiological ResponsesMuscle metabolism and nutritionFibromyalgia and Chronic Fatigue Syndrome Research