RexAB Promotes the Survival of Staphylococcus aureus Exposed to Multiple Classes of Antibiotics
Rebecca S. Clarke, Kam Pou Ha, Andrew M. Edwards
Abstract
mutant under anaerobic conditions, indicative of a role for reactive oxygen species in mediating DNA damage. Taken together, this work confirms previous observations that several classes of antibiotics cause DNA damage in S. aureus and extends them by showing that processing of DNA double-strand breaks by RexAB is a major trigger of the mutagenic SOS response and promotes bacterial survival.
Topics & Concepts
SOS responseDNA damageAntibioticsMicrobiologyBiologyStaphylococcus aureusDNADNA repairMultidrug toleranceMutantBacteriaGeneticsGeneBiofilmAntibiotic Resistance in BacteriaAntimicrobial Resistance in StaphylococcusBacterial Genetics and Biotechnology