Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia
Gretchen Johnston, Haley E. Ramsey, Qi Liu, Jing Wang, Kristy R. Stengel, Shilpa Sampathi, Pankaj Acharya, Maria P. Arrate, Matthew C. Stubbs, Timothy C. Burn, Michael R. Savona, Scott W. Hiebert
Topics & Concepts
BiologyMyeloid leukemiaCancer researchProgenitor cellMyeloidChromatinLeukemiaTranscriptomeAzacitidineStem cellTranscription factorGene expressionGeneMolecular biologyCell biologyGeneticsDNA methylationEpigenetics and DNA MethylationAcute Myeloid Leukemia ResearchImmune cells in cancer