Identification of a druggable protein–protein interaction site between mutant p53 and its stabilizing chaperone DNAJA1
Xin Tong, Dandan Xu, Rama K. Mishra, Ryan Jones, Leyu Sun, Gary E. Schiltz, Jie Liao, Guang‐Yu Yang
Abstract
complex is critical for mutp53's stability and oncogenic function, and DNAJA1 is a robust therapeutic target for developing the efficient small molecule inhibitors against oncogenic mutp53.
Topics & Concepts
DruggabilityMutantChaperone (clinical)ChemistryCell biologyCo-chaperoneP53 proteinMutant proteinHsp90BiologyBiochemistryHeat shock proteinMedicineGenePathologyCancer-related Molecular PathwaysDNA Repair MechanismsRNA Research and Splicing