The Antitumor and Sorafenib-resistant Reversal Effects of Ursolic Acid on Hepatocellular Carcinoma via Targeting ING5
Yinjie Fan, Fu-Zhi Pan, Zheng‐Guo Cui, Zheng Hua-chuan
Abstract
experiments since T antigen upregulated ING5 expression by inhibiting the ubiquitin-mediated degradation and promoting the T antigen-SRF-YY1-ING5 complex-associated transcription. UA suppressed JCPyV T antigen-induced spontaneous HCC through inhibiting ING5-mediated PI3K/Akt signaling pathway. These findings suggest that UA has the dual antitumoral functions of inhibiting hepatocellular carcinogenesis and reversing sorafenib resistance of HCC cells through targeting ING5, which could serve as a potential therapeutic strategy for HCC.
Topics & Concepts
SorafenibCancer researchHepatocellular carcinomaChemistryPI3K/AKT/mTOR pathwayProtein kinase BSignal transductionCarcinogenesisBiologyBiochemistryGeneNatural product bioactivities and synthesisRetinoids in leukemia and cellular processesUbiquitin and proteasome pathways