The Obscure Potential of AHNAK2
Mohamed Zardab, Konstantinos Stasinos, Richard Grose, Hemant M. Kocher
Abstract
AHNAK2 is a protein discovered in 2004, with a strong association with oncogenesis in various epithelial cancers. It has a large 616 kDa tripartite structure and is thought to take part in the formation of large multi-protein complexes. High expression is found in clear cell renal carcinoma, pancreatic ductal adenocarcinoma, uveal melanoma, and lung adenocarcinoma, with a relation to poor prognosis. Little work has been done in exploring the function and relation AHNAK2 has with cancer, with early studies showing promising potential as a future biomarker and therapeutic target.
Topics & Concepts
CarcinogenesisCancer researchAdenocarcinomaBiomarkerCancerPancreatic ductal adenocarcinomaMelanomaMedicineLung cancerPancreatic cancerPathologyBiologyOncologyInternal medicineBiochemistryS100 Proteins and AnnexinsLung Cancer Treatments and MutationsPeptidase Inhibition and Analysis