Cryo-EM structure of 90 <i>S</i> small ribosomal subunit precursors in transition states
Yifei Du, Weidong An, Xing Zhu, Qi Sun, Jia Qi, Keqiong Ye
Abstract
How ribosomes are made The formation of eukaryotic ribosomes is a complex process that starts with transcription of a large precursor RNA that assembles into a large 90S preribosome, which matures to finally give the 40S small subunit of the ribosome. Cheng et al. and Du et al. give insight into this process, using cryo–electron microscopy to look at intermediates along the pathway. Together, these studies reveal how a cast of molecular players act to coordinate the compositional and structural changes that transform the 90S preribosome into a pre-40S subunit. Science , this issue p. 1470 , p. 1477
Topics & Concepts
RibosomeEukaryotic RibosomeProtein subunitEukaryotic Small Ribosomal SubunitRibosomal RNAEukaryotic Large Ribosomal SubunitTranscription (linguistics)ChemistryStructural biologyCell biologyBiologyCrystallographyBiophysicsRNABiochemistryGenePhilosophyLinguisticsRNA modifications and cancerRNA and protein synthesis mechanismsRNA Research and Splicing