Enceleamycins A–C, Furo-Naphthoquinones from <i>Amycolatopsis</i> sp. MCC0218: Isolation, Structure Elucidation, and Antimicrobial Activity
Abujunaid Habib Khan, Madhukar S. Said, Balasaheb R. Borade, Rajesh G. Gonnade, Vitthal T. Barvkar, Ravindar Kontham, Syed G. Dastager
Abstract
Three novel furo-naphthoquinones, enceleamycins A–C (1–3), and a new N-hydroxypyrazinone acid (4) were identified from the strain Amycolatopsis sp. MCC 0218, isolated from a soil sample collected from the Western Ghats of India. Their chemical structure and absolute and relative configurations were established by 1D and 2D NMR spectroscopy, single-crystal X-ray crystallography, and high-resolution mass spectrometry. Compounds 1 and 3 were active against methicillin-susceptible and -resistant Staphylococcus aureus with MIC values of 2–16 μg/mL.
Topics & Concepts
AntimicrobialMass spectrometryHigh resolutionStaphylococcus aureusStereochemistryChemistryNuclear magnetic resonance spectroscopyTwo-dimensional nuclear magnetic resonance spectroscopyAntibacterial activityStrain (injury)Isolation (microbiology)Absolute configurationMicrobiologyBacteriaBiologyOrganic chemistryChromatographyGeographyAnatomyGeneticsRemote sensingMicrobial Natural Products and BiosynthesisAntimicrobial Resistance in StaphylococcusBiochemical and Structural Characterization