Kinetic resolution of<i>N</i>-aryl β-amino alcohols<i>via</i>asymmetric aminations of anilines
Zheng Guo, Jinglei Xie, Tao Hu, Yunrong Chen, Houchao Tao, Xiaoyu Yang
Abstract
-aminations of anilines with azodicarboxylates enabled by chiral phosphoric acid catalysis. Broad substrate scope and high kinetic resolution performances were afforded with this method. Control experiments supported the critical roles of the NH and OH group in these reactions.
Topics & Concepts
Kinetic resolutionArylChemistrySubstrate (aquarium)Phosphoric acidCatalysisResolution (logic)Kinetic energyCombinatorial chemistryOrganic chemistryEnantioselective synthesisPhysicsComputer scienceGeologyAlkylQuantum mechanicsArtificial intelligenceOceanographySynthesis and Catalytic ReactionsAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods