Hypochlorous Acid Can Be the Novel Option for the Meibomian Gland Dysfunction Dry Eye through Ultrasonic Atomization
Zhiyuan Li, Haiyan Wang, Liang Mo, Zhenghua Li, Yvliang Li, Xiao‐Ping Zhou, Guoping Kuang
Abstract
Background. Dry eye is a multifactor disease which needs comprehensive treatments to keep the homeostasis of ocular surface. Objective. To explore the effect of hypochlorous acid on the meibomian gland dysfunction dry eye through ultrasonic atomization. Methods. We set this study of 0.01% HOCL and 0.1% hyaluronate by ultrasonic atomization. All the data was recorded at the 1st, 15th, 30th, and 55th days. The patients’ complains, the meibum analysis, conjunctive congestion, corneal staining, Schirmer’s I test, and NIBUT were recorded by K5M, the MMP-9, and IL-2 of tear by inflammation kit; the Demodex was recorded by microscopy. Results. 53 patients have joined this study. There is no statistic difference between them on OSDI (day 15: <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>p</a:mi> <a:mo>=</a:mo> <a:mn>0.061</a:mn> </a:math> , 30: <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"> <c:mi>p</c:mi> <c:mo>=</c:mo> <c:mn>0.055</c:mn> </c:math> , 55: <e:math xmlns:e="http://www.w3.org/1998/Math/MathML" id="M3"> <e:mi>p</e:mi> <e:mo>=</e:mo> <e:mn>0.052</e:mn> </e:math> ); results show the <g:math xmlns:g="http://www.w3.org/1998/Math/MathML" id="M4"> <g:mn>10.57</g:mn> <g:mo>±</g:mo> <g:mn>0.13</g:mn> </g:math> and <i:math xmlns:i="http://www.w3.org/1998/Math/MathML" id="M5"> <i:mn>12.54</i:mn> <i:mo>±</i:mo> <i:mn>0.17</i:mn> </i:math> reduction on OSDI; the differences of both treatments are significant ( <k:math xmlns:k="http://www.w3.org/1998/Math/MathML" id="M6"> <k:msup> <k:mrow/> <k:mrow> <k:mo>∗</k:mo> <k:mrow> <k:mo>∗</k:mo> </k:mrow> </k:mrow> </k:msup> <k:mi>p</k:mi> <k:mo><</k:mo> <k:mn>0.01</k:mn> </k:math> ). Increased Schirmer’s and TBUT are <m:math xmlns:m="http://www.w3.org/1998/Math/MathML" id="M7"> <m:mn>3.27</m:mn> <m:mo>±</m:mo> <m:mn>0.10</m:mn> </m:math> and <o:math xmlns:o="http://www.w3.org/1998/Math/MathML" id="M8"> <o:mn>6.29</o:mn> <o:mo>±</o:mo> <o:mn>0.10</o:mn> </o:math> ( <q:math xmlns:q="http://www.w3.org/1998/Math/MathML" id="M9"> <q:msup> <q:mrow/> <q:mrow> <q:mo>∗</q:mo> <q:mrow> <q:mo>∗</q:mo> </q:mrow> </q:mrow> </q:msup> <q:mi>p</q:mi> <q:mo><</q:mo> <q:mn>0.01</q:mn> </q:math> ) or <s:math xmlns:s="http://www.w3.org/1998/Math/MathML" id="M10"> <s:mn>7.32</s:mn> <s:mo>±</s:mo> <s:mn>1.72</s:mn> </s:math> s and <u:math xmlns:u="http://www.w3.org/1998/Math/MathML" id="M11"> <u:mn>9.22</u:mn> <u:mo>±</u:mo> <u:mn>1.41</u:mn> </u:math> s ( <w:math xmlns:w="http://www.w3.org/1998/Math/MathML" id="M12"> <w:msup> <w:mrow/> <w:mrow> <w:mo>∗</w:mo> </w:mrow> </w:msup> <w:mi>p</w:mi> <w:mo><</w:mo> <w:mn>0.05</w:mn> </w:math> ); the decreased conjunctive and corneal staining are <y:math xmlns:y="http://www.w3.org/1998/Math/MathML" id="M13"> <y:mn>0.23</y:mn> <y:mo>±</y:mo> <y:mn>0.07</y:mn> </y:math> and <ab:math xmlns:ab="http://www.w3.org/1998/Math/MathML" id="M14"> <ab:mn>0.45</ab:mn> <ab:mo>±</ab:mo> <ab:mn>0.06</ab:mn> </ab:math> ( <cb:math xmlns:cb="http://www.w3.org/1998/Math/MathML" id="M15"> <cb:msup> <cb:mrow/> <cb:mrow> <cb:mo>∗</cb:mo> <cb:mrow> <cb:mo>∗</cb:mo> </cb:mrow> </cb:mrow> </cb:msup> <cb:mi>p</cb:mi> <cb:mo><</cb:mo> <cb:mn>0.01</cb:mn> </cb:math> ) or <eb:math xmlns:eb="http://www.w3.org/1998/Math/MathML" id="M16"> <eb:mn>0.42</eb:mn> <eb:mo>±</eb:mo> <eb:mn>0.03</eb:mn> </eb:math> and <gb:math xmlns:gb="http://www.w3.org/1998/Math/MathML" id="M17"> <gb:mn>0.37</gb:mn> <gb:mo>±</gb:mo> <gb:mn>0.02</gb:mn> </gb:math> ( <ib:math xmlns:ib="http://www.w3.org/1998/Math/MathML" id="M18"> <ib:msup> <ib:mrow/> <ib:mrow> <ib:mo>∗</ib:mo> </ib:mrow> </ib:msup> <ib:mi>p</ib:mi> <ib:mo><</ib:mo> <ib:mn>0.05</ib:mn> </ib:math> ) at both groups. The differences of MMP-9 and IL-2 negative rate are significant ( <kb:math xmlns:kb="http://www.w3.org/1998/Math/MathML" id="M19"> <kb:mi>Z</kb:mi> <kb:mo>=</kb:mo> <kb:mn>0.896</kb:mn> </kb:math> , <mb:math xmlns:mb="http://www.w3.org/1998/Math/MathML" id="M20"> <mb:msup> <mb:mrow/> <mb:mrow> <mb:mo>∗</mb:mo> <mb:mrow> <mb:mo>∗</mb:mo> </mb:mrow> </mb:mrow> </mb:msup> <mb:mi>p</mb:mi> <mb:mo>=</mb:mo> <mb:mn>0.002</mb:mn> <mb:mo><</mb:mo> <mb:mn>0.01</mb:mn> </mb:math> ; <ob:math xmlns:ob="http://www.w3.org/1998/Math/MathML" id="M21"> <ob:mi>Z</ob:mi> <ob:mo>=</ob:mo> <ob:mn>0.659</ob:mn> </ob:math> , <qb:math xmlns:qb="http://www.w3.org/1998/Math/MathML" id="M22"> <qb:msup> <qb:mrow/> <qb:mrow> <qb:mo>∗</qb:mo> <qb:mrow> <qb:mo>∗</qb:mo> </qb:mrow> </qb:mrow> </qb:msup> <qb:mi>p</qb:mi> <qb:mo>=</qb:mo> <qb:mn>0.001</qb:mn>