UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex
Jalila Chagraoui, Simon Girard, Jean-François Spinella, Laura Simon, Éric Bonneil, Nadine Mayotte, Tara MacRae, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Céline Moison, Elisa Tomellini, Pierre Thibault, Mike Tyers, Anne Marinier, Guy Sauvageau
Topics & Concepts
BiologyCorepressorCell biologyEpigeneticsUbiquitin ligaseEx vivoUbiquitinHaematopoiesisStem cellIn vivoGeneticsRepressorTranscription factorGeneHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationImmune Cell Function and Interaction