Proton Pump Inhibitor-Induced Gut Dysbiosis Increases Mortality Rates for Patients with Clostridioides difficile Infection
Cheng‐Yu Lin, Hao‐Tsai Cheng, Chia‐Jung Kuo, Yun‐Shien Lee, Chang‐Mu Sung, Micah Keidan, Krishna Rao, John Y. Kao, Sen‐Yung Hsieh
Abstract
This article demonstrates that daily PPI use was the only avoidable risk factor for death. With more extended PPI use, the mortality rate was higher in patients with CDI. Decreases in Prevotella copri and Ruminococcus gnavus and increases in Parabacteroides merdae and Clostridioides difficile in line with daily PPI use duration were significantly associated with the death of CDI patients. Our findings provide in-depth insights into the cautious use of PPIs in chronically ill patients with CDI.
Topics & Concepts
ClostridioidesDysbiosisProton-pump inhibitorClostridium difficileInternal medicineMedicineMicrobiologyGastroenterologyBiologyAntibioticsDiseaseClostridium difficile and Clostridium perfringens researchGastrointestinal motility and disordersGut microbiota and health