Taurochenodeoxycholic acid activates autophagy and suppresses inflammatory responses in microglia of MPTP-induced Parkinson’s disease mice via AMPK/mTOR, AKT/NFκB and Pink1/Parkin signaling pathways mediated by Takeda G protein-coupled receptor 5
Chenyang Ni, Lupeng Wang, Yuyan Bai, Fei Huang, Hailian Shi, Hui Wu, Xiaojun Wu, Jin Huang, Jin Huang
Topics & Concepts
PINK1ParkinPI3K/AKT/mTOR pathwayAutophagyMicrogliaAMPKProtein kinase BMPTPCancer researchCell biologyParkinson's diseaseMedicineNeuroscienceChemistrySignal transductionInflammationKinaseDiseaseImmunologyBiologyInternal medicineProtein kinase AApoptosisBiochemistryAdenosine and Purinergic SignalingParkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms