Copper(<scp>ii</scp>) triflate catalyzed three-component reaction for the synthesis of 2,3-diarylquinoline derivatives using aryl amines, aryl aldehydes and styrene oxides
Saghir Ali, Abu T. Khan
Abstract
An efficient and expedient synthetic protocol is reported for the synthesis of 2,3-diarylquinoline derivatives from readily available aryl amines, aryl aldehydes and styrene oxides using 10 mol% copper(ii) triflate by employing three-component reaction. This approach involves the reaction between the in situ generated imine (derived from the aryl amine and aryl aldehyde) and styrene oxide, which enables the formation of the desired products. The present method has several advantages such as high atom-economy, high regioselectivity, easy handling, consecutive one C-N and two C-C bond formation, shorter reaction time and broader substrate scope with good yields.
Topics & Concepts
ChemistryArylTrifluoromethanesulfonateStyreneCatalysisCopperOrganic chemistryComponent (thermodynamics)Combinatorial chemistryCopolymerAlkylPolymerPhysicsThermodynamicsMulticomponent Synthesis of HeterocyclesSynthesis and biological activityChemical Synthesis and Analysis