Caged polycyclic polyprenylated acylphloroglucinols as Ca<sub>v</sub>3.2 low voltage-gated Ca<sup>2+</sup> channel inhibitors from <i>Hypericum curvisepalum</i>
Yan-Song Ye, Rui Liu, Nana Jiang, Song-Yu Li, Yin Nian, Gang Xu
Abstract
channel inhibitors with negligible effect on the cardiovascular antitarget, the human ether-à-go-go-related gene potassium channel. Additionally, 2 indicates strong antinociception in the mouse acetic acid writhing test.
Topics & Concepts
ChemistryHypericumPhloroglucinolPotassium channelStereochemistryEtherOrganic chemistryBiophysicsTraditional medicineMedicineBiologyNatural Compound Pharmacology StudiesBiological and pharmacological studies of plantsSynthesis of Organic Compounds