Gut-kidney interaction reinforces dapagliflozin-mediated alleviation in diabetic nephropathy
Yinhua Ni, Haimei Du, Lehui Ke, Liujie Zheng, Sujie Nan, Liyang Ni, Yuxiang Pan, Zhengwei Fu, Qiang He, Juan Jin
Abstract
We demonstrated that dapagliflozin administration alleviated renal inflammation and fibrosis in vivo and in vitro, along with reshaping the gut microbiota composition and altering levels of key microbial metabolites, including argininosuccinic acid (ASA) and palmitic acid (PA), while increasing S-allylcysteine (SAC). Importantly, the genera Muribaculaceae and Desulfovibrionaceae emerged as pivotal microbial genera mediating the protective effects of dapagliflozin against diabetic nephropathy.
Topics & Concepts
DapagliflozinDiabetic nephropathyMedicineDiabetes mellitusKidneyInternal medicineEndocrinologyType 2 diabetesDiabetes Treatment and ManagementChronic Kidney Disease and DiabetesDiet and metabolism studies