Targeted delivery of PARP inhibitors to neuronal mitochondria via biomimetic engineered nanosystems in a mouse model of traumatic brain injury
Jiejie Sun, Jingzhou Liu, Chunhong Gao, Chunhong Gao, Jinpeng Zheng, Jinbang Zhang, Yaning Ding, Wei Gong, Meiyan Yang, Zhiping Li, Yuli Wang, Yang Yang, Chunsheng Gao, Chunsheng Gao
Topics & Concepts
Poly ADP ribose polymeraseNeuroprotectionMitochondrionOlaparibTraumatic brain injuryPARP inhibitorPharmacologyProgrammed cell deathDNA damageApoptosisBiologyPolymeraseCell biologyMedicineBiochemistryDNAPsychiatryPARP inhibition in cancer therapyRadiation Therapy and DosimetryNanopore and Nanochannel Transport Studies