Litcius/Paper detail

Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

Derek M. Mason, Simon Friedensohn, Cédric R. Weber, Christian Jordi, Bastian Wagner, Simon M. Meng, Roy A. Ehling, Lucia Bonati, Jan Dahinden, Pablo Gaínza, Bruno E. Correia, Sai T. Reddy

2021Nature Biomedical Engineering323 citationsDOIOpen Access PDF

Topics & Concepts

AntibodyImmunogenicityComputational biologyCRISPRBiologyDirected evolutionDeep sequencingAntigenRecombinant DNAMutagenesisPeptide libraryTrastuzumabMolecular biologyGeneMutationGeneticsPeptide sequenceGenomeCancerMutantBreast cancerMonoclonal and Polyclonal Antibodies ResearchViral Infectious Diseases and Gene Expression in InsectsBiosimilars and Bioanalytical Methods
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning | Litcius