MiR-17-5p promotes the endothelialization of endothelial progenitor cells to facilitate the vascular repair of aneurysm by regulating PTEN-mediated PI3K/AKT/VEGFA pathway
Ye Tian, Xinxi Li, Chao Bai, Zhenwei Yang, Lei Zhang, Jun Luo
Abstract
study: miR-17-5p overexpression promoted the viability, migration, and tube formation of EPCs, up-regulated the expressions of VEGFA, p-PI3K, and p-AKT, and down-regulated the PTEN expression in EPCs; miR-17-5p silencing did the opposite; PTEN was targeted by miR-17-3p and further abrogated the effects of miR-17-5p overexpression on EPCs. MiR-17-5p promoted the endothelialization of EPCs to facilitate the vascular repair of aneurysm by regulating PTEN-mediated PI3K/AKT/VEGFA pathway.
Topics & Concepts
PTENProgenitor cellAngiogenesisPI3K/AKT/mTOR pathwayBiologyCancer researchFlow cytometryProtein kinase BEndothelial progenitor cellCell biologyImmunologySignal transductionStem cellAngiogenesis and VEGF in CancerVascular Anomalies and TreatmentsAortic aneurysm repair treatments