Heterocyclic Boron Acid Catalyzed Dehydrative Amidation of Aliphatic/Aromatic Carboxylic Acids with Amines
Bin Pan, Dingmin Huang, Haotian Sun, Shengnan Song, Xianbin Su
Abstract
A commercially available and versatile dehydrative amidation catalyst, featuring a thianthrene boron acid structure, has been developed. The catalyst shows high catalytic activity to both aliphatic and less reactive aromatic carboxylic acid substrates, including several bioactive or clinical molecules with a carboxylic acid group.
Topics & Concepts
ChemistryCatalysisCarboxylic acidBoronOrganic chemistryMoleculeCombinatorial chemistryChemical Synthesis and AnalysisChemical Synthesis and ReactionsAsymmetric Synthesis and Catalysis