Surface chemistry mediates the tumor entrance of nanoparticles probed using single-molecule dual-imaging nanodots
Huiming Ren, Qiuhui Hu, Yuji Sun, Xiaoxuan Zhou, Yincong Zhu, Qiuyang Dong, Linying Chen, Jianbin Tang, Hongjie Hu, Youqing Shen, Zhuxian Zhou
Abstract
29%) than G6-OEG. Therefore, G6-Ac is more likely to undergo intercellular transport through cell transcytosis, and is able to reach a tumor area distant from blood vessels, while G6-OEG mainly enters the tumor through enhanced permeability and retention (EPR) effect-based passive transport, and is not able to deliver to distant tumor areas. This study suggests that it is possible to boost the tumor entrance of nanoparticles by engineering surface chemistry for active transport.
Topics & Concepts
TranscytosisChemistryNanodotBiophysicsNanoparticleTumor microenvironmentDendrimerEthylene glycolNanotechnologyEndocytosisMaterials scienceTumor cellsCellBiochemistryBiologyOrganic chemistryPhysical chemistryCancer researchNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniques