Litcius/Paper detail

Exploring the intersection of mechanobiology and artificial intelligence

Roger Oria, Kashish Jain, Valerie M. Weaver

2025npj Biological Physics and Mechanics.14 citationsDOIOpen Access PDF

Abstract

The rapid increase in cell biology techniques, combined with high-throughput technologies and improved computing, has yielded complex data that classical methods struggle to analyze. The question arises, can a machine overcome human performance to identify and predict distinct biological scenarios? Here, we review the mechanotransduction of extracellular matrix mechanical cues and how Artificial Intelligence-based methodologies are or can be used to predict cell states based on morphological and genetic signatures.

Topics & Concepts

MechanobiologyIntersection (aeronautics)Computer scienceArtificial intelligenceCognitive scienceEngineeringBiologyPsychologyAnatomyAerospace engineeringCellular Mechanics and InteractionsCell Image Analysis Techniques