Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors
Dou Dou, Jie Wang, Yunjin Qiao, Gulinuer Wumaier, Wenjie Sha, Wenjie Li, Wenyi Mei, Tingyuan Yang, Chen Zhang, Huan He, Caolin Wang, Linna Chu, Baihui Sun, Rongrong Su, Xiangyu Ma, Mengdie Gong, Xie Lijuan, Wenzhe Jiang, Yanyan Diao, Lili Zhu, Zhenjiang Zhao, Zhuo Chen, Yufang Xu, Shengqing Li, Honglin Li
Topics & Concepts
T790MChemistryAllosteric regulationEGFR inhibitorsOsimertinibEpidermal growth factor receptorPharmacologyBinding siteIn vivoCancer researchBiochemistryReceptorErlotinibGefitinibBiologyBiotechnologyLung Cancer Treatments and MutationsCancer therapeutics and mechanismsLung Cancer Research Studies