Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors
Meijia Yang, Xin Tang, Zongliang Zhang, Lei Gu, Wei Heng, Shasha Zhao, Kunhong Zhong, Min Mu, Cheng Huang, Caiying Jiang, Jianguo Xu, Gang Guo, Liangxue Zhou, Aiping Tong
Abstract
Purpose: Given that heterogeneous expression and variants of antigens on solid tumors are responsible for relapse after chimeric antigen receptor (CAR)-T cell therapy, we hypothesized that combinatorial targeting two tumor-associated antigens would lessen this problem and enhance the antitumor activity of T cells.
Topics & Concepts
AntigenChimeric antigen receptorCancer researchAntibodyBiologyMelanomaCancer immunotherapyImmunotherapyImmunologyImmune systemCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design