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1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and <i>in silico</i> studies

Mohamed Hagras, Marwa A. Saleh, Rogy R. Ezz Eldin, Abdelrahman A. Abuelkhir, Emad Gamil Khidr, Ahmed A. El-Husseiny, Hesham A. El-Mahdy, Eslam B. Elkaeed, Ibrahim H. Eissa

2021Journal of Enzyme Inhibition and Medicinal Chemistry47 citationsDOIOpen Access PDF

Abstract

studies were performed including docking, ADMET, and toxicity studies to predict binding mode against VEGFR-2 and to anticipate pharmacokinetic, drug-likeness, and toxicity of the synthesised compounds.

Topics & Concepts

In silicoCytotoxicityChemistryApoptosisOxadiazoleDocking (animal)In vitroCell cultureCell growthPharmacologyBiochemistryBiologyOrganic chemistryGeneNursingGeneticsMedicineAngiogenesis and VEGF in CancerSynthesis and biological activity
1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and <i>in silico</i> studies | Litcius