Functions of RNA-Binding Proteins in Cardiovascular Disease
Grégoire Ruffenach, Lejla Medzikovic, Wasila Sun, Jason Hong, Mansoureh Eghbali
Abstract
Gene expression is under tight regulation from the chromatin structure that regulates gene accessibility by the transcription machinery to protein degradation. At the transcript level, this regulation falls on RNA-binding proteins (RBPs). RBPs are a large and diverse class of proteins involved in all aspects of a transcript's lifecycle: splicing and maturation, localization, stability, and translation. In the past few years, our understanding of the role of RBPs in cardiovascular diseases has expanded. Here, we discuss the general structure and function of RBPs and the latest discoveries of their role in pulmonary and systemic cardiovascular diseases.
Topics & Concepts
RNA-binding proteinRNA splicingChromatinBiologyTranslation (biology)Computational biologyAlternative splicingGene expressionGeneRegulation of gene expressionMessenger RNARNARna processingGeneticsCell biologyRNA Research and SplicingRNA and protein synthesis mechanismsRNA modifications and cancer