Direct interaction between <i>Lactiplantibacillus plantarum</i> ZJ316-derived lipoteichoic acid and TLR2 mediates anti-inflammatory and barrier-protective effects in intestinal cells
Jiarun Han, Lina Ding, Xin Zhao, Jiaqi Liu, Jiaqi Yin, Qi Wang, Ping Li, Qing Gu
Abstract
Lipoteichoic acid (LTA) from L. plantarum ZJ316 binds TLR2 to suppress MAPK signaling, reduce inflammation, and enhance epithelial barrier function, revealing its potential as a gut-protective bioactive via the TLR2-MAPK pathway.
Topics & Concepts
Lipoteichoic acidTLR2ChemistryMicrobiologyBiologyBiochemistryBacteriaInnate immune systemReceptorStaphylococcus aureusGeneticsProbiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologySeaweed-derived Bioactive Compounds