Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps
Mu Xian, Bing Yan, Xicheng Song, Jianjun Chen, Jun Tang, Yan Jiang, Lijia Wan, Wen Liu, Jinmei Xue, Zhiwei Cao, Yafeng Yu, Xiangli Yang, Shi Li, Guangke Wang, Yu Xu, Yucheng Yang, Jing Ye, Luyun Jiang, Fang Quan, Guolin Tan, Feng Liu, Zhendong Xu, Xiaowen Zhang, Jiping Li, Lizhong Su, Yi Yang, Jiangang Fan, Gang He, Li Zhu, Xiangdong Wang, Ming Wang, Shen Shen, Jian Li, Huabin Li, Xin Wei, Hongmeng Yu, Zheng Liu, Ruixia Ma, Huanhai Liu, Jianfeng Liu, Wei Lv, Qintai Yang, Dongdong Zhu, Lei Cheng, Chengshuo Wang, Luo Zhang
Abstract
Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of registered biologics for CRSwNP treatment in China, the country is experiencing rapid development in this field. It is imperative to standardize the application of biologic agents in CRSwNP management in preparation for their future integration into the CRSwNP care pathway. The Rhinology Group, Chinese Society of Otorhinolaryngology-Head and Neck Surgery; the Rhinology Group, Chinese Medical Doctor Association of Otorhinolaryngology-Head and Neck Surgery; and the Nasal and Ocular Allergy Group, Chinese Society of Allergy have convened an expert panel consisting of principal investigators experienced in clinical trials of biologic treatment for CRSwNP. This expert panel was assembled to discuss the application of biologic agents in patients with CRSwNP in China. Additionally, the latest findings on the pathogenesis of CRSwNP, mechanisms of biologic agents, and efficacy and safety of biologic treatment in patients with CRSwNP were reviewed, with a special emphasis on research evidence from China. The expert panel reached a consensus on several critical issues, including criteria for the prescription, treatment course, and efficacy evaluation from a Chinese perspective. This position paper aims to guide Chinese physicians in the use of biologic agents for patients with CRSwNP. As our experience with biologic treatment continues to grow, this position paper will be further updated.