The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer
Zhongyuan Wang, Liang Zhou, Yejun Wang, Quanzhou Peng, Huan Li, Xin Zhang, Zijie Su, Jiaxing Song, Qi Sun, Sapna Sayed, Shanshan Liu, Desheng Lu
Abstract
Our results revealed that the CK1δ/ε-AES axis is important for CRC tumorigenesis and metastasis, and targeted inhibition of this axis may be a potential therapeutic strategy for CRC.
Topics & Concepts
Wnt signaling pathwayColorectal cancerCancer researchCasein kinase 1MetastasisSKP2CarcinogenesisWestern blotCancerMedicineUbiquitinBiologyChemistryUbiquitin ligaseInternal medicinePhosphorylationSignal transductionCell biologyGeneProtein kinase ABiochemistryCancer-related gene regulationHedgehog Signaling Pathway StudiesEpigenetics and DNA Methylation