Dual-mode optical biosensor based on multi-functional DNA structures for detecting bioactive small molecules
Li Guo, Dandan Chen, Huijie Wang, Xinzhu Meng, Yongcun Yan, Shuangcheng Zhi, Senquan Dai, Sai Bi
Abstract
Semiconducting polymer dots and hemin-functionalized DNA nanoflowers with excellent peroxidase-like activity and high fluorescent brightness are prepared for fluorescent/colorimetric dual-mode sensing of dopamine and glutathione as low as nM and μM, respectively. This biosensor is readily applied to the analysis of complicated biological samples with high selectivity and accuracy, which opens up promising prospects in clinical applications.
Topics & Concepts
BiosensorDNAMoleculeCombinatorial chemistryChemistryDual modeNanotechnologySmall moleculeMaterials scienceBiophysicsBiochemistryBiologyOrganic chemistryEngineeringAerospace engineeringAdvanced biosensing and bioanalysis techniquesAdvanced Biosensing Techniques and ApplicationsBiosensors and Analytical Detection