Inter- and intratumor DNA methylation heterogeneity associated with lymph node metastasis and prognosis of esophageal squamous cell carcinoma
Huajing Teng, Meiying Xue, Jialong Liang, Xingxing Wang, Lu Wang, Wenqing Wei, Chao Li, Ze Zhang, Qinglan Li, Ran Xia, Xiaohui Shi, Wanshi Cai, Weihu Wang, Hengjun Gao, Zhong Sheng Sun
Abstract
: This study presents the first population-level resource for dissecting base-resolution DNAm variation in ESCC and provides novel insights into the ESCC pathogenesis and progression, which might facilitate diagnosis and prognosis for this prevalent malignancy.
Topics & Concepts
Esophageal squamous cell carcinomaDNA methylationCancer researchCarcinomaBasal cellLymph node metastasisPathologyMetastasisOncologyMedicineMethylationDNABiologyInternal medicineCancerGeneGene expressionGeneticsEpigenetics and DNA MethylationCancer Genomics and DiagnosticsRNA modifications and cancer