Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder
Junjian Hu, Hongwu Wang, Xitang Li, Yonggang Liu, Yuqiang Mi, Hongyan Kong, Xi Dong, Weiming Yan, Xiaoping Luo, Qin Ning, Xiaojing Wang
Abstract
These data suggest that fgl2 aggravates the progression of NASH through activation of NF-κB, p38-MAPK and NLRP3 inflammasomes in macrophages, which consequently induces overproduction of proinflammatory cytokines and lipid metabolism disorders. An interaction of fgl2 and TLR4 may in part contribute to the activation of inflammatory signaling pathways in macrophages.
Topics & Concepts
InflammationNonalcoholic steatohepatitisFibrinogenTLR4Lipid metabolismSteatohepatitisChemistryNonalcoholic fatty liver diseaseLipid Metabolism DisorderEndocrinologyInternal medicineBiochemistryMedicineFatty liverCholesterolBlood lipidsDiseaseLiver Disease Diagnosis and TreatmentLipid metabolism and disordersPancreatitis Pathology and Treatment