Design, synthesis and anti-AD effects of dual inhibitor targeting glutaminyl cyclase/GSK-3β
Yazhou Xie, Chen Chen, Shujing Lin, Xi Yu, Shuixian Ye, Xiaojie Chen, Na Ouyang, Wei Xiong, Chenyang Li, Chenshu Xu, Guo-Li Song, Haiqiang Wu
Topics & Concepts
ChemistryPotencyGSK-3Glycogen synthaseMaleimideStereochemistryIC50KinaseImidazolePharmacologyEnzymeBiochemistryIn vitroMedicinePolymer chemistryCarbohydrate Chemistry and SynthesisPolyamine Metabolism and ApplicationsProtein Kinase Regulation and GTPase Signaling