Coumarin-acetohydrazide derivatives as novel antiproliferative agents <i>via</i> VEGFR-2/AKT axis inhibition and apoptosis triggering
Lina M. A. Abdel Ghany, Nehad M. El‐Dydamony, Amira A. Helwa, Sahar M. Abdelraouf, Rana M. Abdelnaby
Abstract
The VEGFR-2/AKT pathway is a crucial axis in tumor survival where it is highly dysregulated in many cancer types.
Topics & Concepts
ChemistryCoumarinApoptosisProtein kinase BCombinatorial chemistryStereochemistryCancer researchBiochemistryOrganic chemistryBiologyPI3K/AKT/mTOR signaling in cancerSynthesis and biological activityPlant chemical constituents analysis