Access to <i>N</i>-Carbonyl Derivatives of Iminosydnones by Carbonylimidazolium Activation
Margaux Riomet, Karine Porte, Léa Madegard, P. Thuéry, Davide Audisio, Frédéric Taran
Abstract
-exocyclic functionalization of iminosydnones was developed involving the addition of a large variety of nucleophiles on carbonyl-imidazolium-activated iminosydnones. This practical and highly versatile method provided access to new classes of iminosydnones and opened a straightforward synthetic route to prepare iminosydnone-based prodrugs.
Topics & Concepts
ChemistryNucleophileSurface modificationProdrugCombinatorial chemistryCarbonyl groupOrganic chemistryStereochemistryCatalysisBiochemistryPhysical chemistrySynthesis and Catalytic ReactionsSynthetic Organic Chemistry MethodsAdvanced Synthetic Organic Chemistry