Light‐Promoted Copper‐Catalyzed Enantioselective Alkylation of Azoles
Chen Li, Bin Chen, Xiaodong Ma, Xueling Mo, Guozhu Zhang
Abstract
A catalytic asymmetric alkylation of azoles with secondary 1-arylalkyl bromides through direct C-H functionalization is reported. Under blue-light photoexcitation, a copper(I)/carbazole-based bisoxazoline (CbzBox) catalytic system exhibits good reactivity and high stereoselectivity, thus offering an efficient strategy for the construction of chiral alkyl azoles. These reactions proceed at low temperature and are compatible with a wide range of azoles.
Topics & Concepts
AlkylationEnantioselective synthesisCatalysisChemistryCopperReactivity (psychology)AlkylCombinatorial chemistrySurface modificationCarbazoleStereoselectivityOrganic chemistryMedicinePhysical chemistryPathologyAlternative medicineCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions