A vascularized crypt-patterned colon model for high-throughput drug screening and disease modelling
Alexander Sotra, Kimia Asadi Jozani, Boyang Zhang
Abstract
-like stromal basal-to-apical cytokine gradients in tissues with vascularized crypts and gradient reversals upon inflammation. Taken together, we demonstrated crypt topography integrated with underlying perfusable microvasculature has significant value for emulating colon physiology and in advanced disease modelling.
Topics & Concepts
CryptColorectal cancerInflammatory bowel diseaseStromal cellPathologyMedicineColitisEpitheliumCancer researchImmunologyDiseaseInternal medicineCancerCancer Cells and Metastasis3D Printing in Biomedical ResearchImmune cells in cancer