NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.
Dong‐Seol Lee, Song Yi Roh, Hojae Choi, Joo‐Cheol Park
Abstract
mice, whereas that of cyclin D1 was downregulated. Our findings suggest that Nfic may contribute to postnatal chondrocyte proliferation by inhibiting p21 expression and by increasing the stability of cyclin D1 protein.
Topics & Concepts
ChondrocyteCell biologyCartilageEndochondral ossificationCyclin D1Mesenchymal stem cellChemistryCell growthOsteocyteAnatomyCell cycleBiologyCellOsteoblastBiochemistryIn vitroMicroRNA in disease regulationBone Metabolism and DiseasesRNA Research and Splicing