mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
Sang Ah Yi, Sara Sepic, Brenda A. Schulman, Alban Ordureau, Heeseon An
Topics & Concepts
DegronBiologyUbiquitin ligaseDNA ligasemTORC1ATP synthaseCell biologyDegradation (telecommunications)Ubiquitin-Protein LigasesBiochemistryUbiquitinEnzymePhosphorylationGeneProtein kinase BComputer scienceTelecommunicationsUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsPI3K/AKT/mTOR signaling in cancer