Enzyme Therapeutic for Ischemia and Reperfusion Injury in Organ Transplantation
Ran Yan, Jie Ren, Jing Wen, Zheng Cao, Di Wu, Meng Qin, Duo Xu, Roxanne Castillo, Feifei Li, Fang Wang, Zhihua Gan, Chaoyong Liu, Ping Wei, Yunfeng Lu
Abstract
Ischemia-reperfusion injury (IRI) remains as a critical challenge for organ transplantation. Herein, an enzyme therapeutic based on superoxide dismutase and catalase for effective mitigation of IRI and pathogen-induced liver injury is reported, providing a therapeutic for organ transplantation and other diseases.
Topics & Concepts
Reperfusion injuryTransplantationOrgan transplantationCatalaseSuperoxide dismutaseIschemiaPharmacologyMedicineLiver transplantationEnzymeTherapeutic effectBiochemistryInternal medicineOxidative stressBiologyHeme Oxygenase-1 and Carbon MonoxideAcute Kidney Injury ResearchCardiac Ischemia and Reperfusion