Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis
Arijit Chakraborty, Asel Kabashi, Samuel Wilk, Laurence G. Rahme
Abstract
This work sheds new light on how P. aeruginosa limits bacterial clearance in macrophages through 2-aminoacetophenone (2-AA), a secreted signaling molecule by this pathogen that is regulated by the quorum-sensing transcription factor MvfR. The action of 2-AA on the lipid biosynthesis gene Scd1 and the autophagic genes ULK1 and Beclin1 appears to secure the reduced intracellular clearance of P. aeruginosa by macrophages.
Topics & Concepts
Pseudomonas aeruginosaQuorum sensingAutophagyTranscription factorCell biologyCell signalingChemistryMicrobiologySignal transductionEpigeneticsGeneIntracellularPathogenVirulenceBiologyBacteriaBiochemistryGeneticsApoptosisBacterial biofilms and quorum sensingCystic Fibrosis Research AdvancesVibrio bacteria research studies