Cardiolipin, and not monolysocardiolipin, preferentially binds to the interface of complexes III and IV
Robin A. Corey, Noah Harrison, Philllp J. Stansfeld, Mark S.P. Sansom, Anna L. Duncan
Abstract
CIV supercomplex show that this interface site is maintained between species. Our study suggests that MLCL accumulation in people with BTHS disrupts supercomplex stability by formation of relatively weak interactions at the interface lipid binding site.
Topics & Concepts
CardiolipinChemistryInterface (matter)MitochondrionBiophysicsBiochemistryBiologyMembranePulmonary surfactantPhospholipidGibbs isothermMitochondrial Function and PathologyATP Synthase and ATPases ResearchAdvanced NMR Techniques and Applications