Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses
Maximes Bessières, Vincent Roy, Tuniyazi Abuduani, Patrick Favetta, Robert Snoeck, Graciela Andreï, Jennifer F. Moffat, Franck Gallardo, Luigi A. Agrofoglio
Topics & Concepts
ProdrugChemistryVaricella zoster virusThymidine kinaseStereochemistryEC50PhosphonateNucleosideVirusNucleoside analogueHerpes simplex virusIn vitroVirologyBiochemistryBiologyHIV/AIDS drug development and treatmentBiochemical and Molecular ResearchPneumocystis jirovecii pneumonia detection and treatment