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N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay

Takeru Furuya, Adam B. Shapiro, Janelle Comita-Prevoir, Eric J. Kuenstner, Jing Zhang, Seth Ribe, April Chen, Daniel J. Hines, Samir H. Moussa, Nicole Carter, Mark Sylvester, Jan Antoinette C. Romero, Camilo V. Vega, M. Sacco, Yu Chen, John P. O’Donnell, Thomas F. Durand-Réville, Alita A. Miller, Rubén Tommasi

2020Bioorganic & Medicinal Chemistry20 citationsDOIOpen Access PDF

Topics & Concepts

Hydroxamic acidChemistryEscherichia coliPotencyIn vivoPseudomonas aeruginosaPharmacologyBiochemistryBacteriaIn vitroStereochemistryBiologyGeneticsGeneBiotechnologyAntibiotic Resistance in BacteriaTuberculosis Research and EpidemiologyHIV/AIDS drug development and treatment
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay | Litcius