PD-1/PD-L1 enhanced cisplatin resistance in gastric cancer through PI3K/AKT mediated P-gp expression
Lijun Wu, Shiyi Cai, Yiyun Deng, Zhe Zhang, Xie-Hai Zhou, Yong Su, Dujuan Xu
Topics & Concepts
PI3K/AKT/mTOR pathwayCisplatinCancer researchProtein kinase BCancer cellPD-L1CancerWestern blotFlow cytometryDownregulation and upregulationMTT assayBiologyMolecular biologyChemistryImmune systemSignal transductionCell growthImmunologyCell biologyImmunotherapyBiochemistryChemotherapyGeneGeneticsCancer Immunotherapy and BiomarkersAdvanced Breast Cancer TherapiesImmune Cell Function and Interaction