A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19
Steffen Jockusch, Chuanjuan Tao, Xiaoxu Li, Thomas K. Anderson, Minchen Chien, Shiv Kumar, James J. Russo, Robert N. Kirchdoerfer, Jingyue Ju
Topics & Concepts
PolymeraseNucleotideCoronavirusNucleoside triphosphateRNA polymeraseProcessivityExonucleaseRNA-dependent RNA polymeraseBiologyVirologyDNA polymeraseRNAChemistryBiochemistryMolecular biologyDNACoronavirus disease 2019 (COVID-19)GeneDiseaseMedicinePathologyInfectious disease (medical specialty)Viral Infections and Immunology ResearchSARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testing