Anti-Markovnikov Hydroacylation of Aryl Alkenes with Aldehydes Enabled by Photo/Cobalt Dual Catalysis
Guanghao Ji, Xuan Li, Jing Zhang
Abstract
Herein we describe a dual photo/cobalt-catalyzed anti-Markovnikov hydroacylation of aryl alkenes using aldehyde as acyl source. The key to success is the cobalt catalyzed hydrogen atom transfer, which enables effective formation of the desired products and efficient regeneration of the photocatalyst under mild conditions. This protocol features broad substrate scopes, good functional group tolerance, high efficiency and regioselectivity.
Topics & Concepts
HydroacylationMarkovnikov's ruleChemistryArylCatalysisCobaltRegioselectivityAldehydeCombinatorial chemistrySubstrate (aquarium)Atom economyOrganic chemistryAlkylOceanographyGeologySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions